The expression and relation of HLA, β2 -microglobulin and receptor for marmoset red blood cells on man/mouse and man/Chinese hamster hybrid cells
✍ Scribed by M. Fellous; J. Wiels; M. C. Hors; R. Rebourcet; C. Finaz; D. Weil; S. Heuertz; G. Mahouy; W. H. Fridman
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 467 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
Abstract
The expression of HLA, human and mouse β~2~‐microglobulin (β~2~m), P red blood cell antigen and a receptor for marmoset red blood cells (MaRBC) were studied on 18 man/mouse and man/Chinese hamster hybrids. A positive correlation was found between the expression of HLA, P, and the receptor for MaRBC, which we interpret as a possible synteny between these different loci. We studied 3 hybrid clones where HLA antigens are still expressed despite the absence of human β~2~m and where redistribution experiments demonstrate that HLA is associated with mouse β~2~m. Synteny between HLA and the receptor for MaRBC can be a useful tool to select HLA‐positive hybrid clones.