## Abstract The molecular basis of the human group IIA secretory phospholipase A~2~ inactivation by bolinaquinone (BLQ), a hydroxyquinone marine terpenoid, has been investigated for the comprehension of its relevant antiinflammatory properties, through the combination of spectroscopic techniques, b
The expression and distribution of group IIA phospholipase A2 in human colorectal tumours
✍ Scribed by Tuulia Avoranta; Jari Sundström; Eija Korkeila; Kari Syrjänen; Seppo Pyrhönen; Jukka Laine
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 753 KB
- Volume
- 457
- Category
- Article
- ISSN
- 1432-2307
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## Abstract It is well known that the expression level of secretory group IIA phospholipase A~2~ (sPLA~2~‐IIA) is elevated in inflammatory diseases and lipopolysaccharide (LPS) up‐regulates the expression of sPLA~2~‐IIA in human umbilical vein endothelial cells (HUVECs). Recently, lower concentrati
Phospholipase A 2 IIA (PLA 2 IIA), which plays a crucial role in arachidonic acid metabolism and in inflammation, is upregulated under various pathological conditions, including in the gallbladder and gallbladder bile from patients with multiple cholesterol gallstones, in the liver and kidney of rat