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The excretion in urine of four insecticidal carbamates and their phenolic metabolites after oral administration to rats

โœ Scribed by F. Hoof; A. Heyndrickx

Publisher
Springer-Verlag
Year
1975
Tongue
English
Weight
431 KB
Volume
34
Category
Article
ISSN
0340-5761

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โœฆ Synopsis

4 insecticidal carbamates: 3-methyl, 5-isopropylphenyl N-methyl-carbamate (Promecarb), 4-methylthio, 3,5 dimethylphenyl N-methylcarbamate (Mesurol), 4-dimethyl-amino, 3,5 dimethylphenyl N-methylcarbamate (Zectran), and 4-benzothienyl N-methyl-carbamate (Mobam) were orally administered to male Wistar rats. The excretion of the unchanged products was followed in 24 hrs urine collections. The corresponding phenols of the different carbamates could be identified as metabolites by gas-chromatography-mass spectrometyr. These metabolites were quantified afterward by gas-liquid chromatography. In all cases only minor quantities of unchanged products and metabolites were excreted in the urine over the 48 hrs after administration.

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