The distribution and excretion of sodium 2,3-dimercapto-1,3 14C-propane-1-sulfonate as dependent on time has been studied in the rat. The highest concentration is found in the kidneys, the lowest in the brain. The excretion is very rapid (T1/2 = 19 min) and follows a monoexponential curve during the
The excretion and distribution of inorganic mercury in the rat as influenced by several chelating agents
โ Scribed by B. Gabard
- Publisher
- Springer-Verlag
- Year
- 1976
- Tongue
- English
- Weight
- 496 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0340-5761
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โฆ Synopsis
Among 15 chelating agents tested, sodium-2,3-dimercaptopropane 1 sulfonate (DMPS), 2,3-dimercaptopropanol (BAL), sodium-mercaptoethyliminodiacetate (MEIDA), and D-penicillamine (PA) exerted an influence on the excretion of Hg and its distribution in the organs. The excretion pattern however, is different for these compounds, and, from the practical point of view, a favourable effect is exhibited only by DMPS which enhances the urinary excretion rate and lowers the Hg-concentration in all organs.
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