The excess burden of stroke in hospitalized adults with sickle cell disease
β Scribed by John J. Strouse; Lori C. Jordan; Sophie Lanzkron; James F. Casella
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 110 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0361-8609
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## Abstract Sickle cell disease (SCD) is a prevalent genetic disorder in which sickle hemoglobin leads to tissue hypoxia and adverse effects on bone. Published studies suggest that children with SCD often have undiagnosed osteopenia or osteoporosis. Minimal data exist on the prevalence of low bone
The clinical and biological heterogeneity of sickle cell hemoglobin (Hb) C disease (SC disease) is similar to sickle cell anemia, but has a much milder course. The effect of genetic factors such as β£ thalassemia or β€-globin gene haplotype has been analyzed in a limited number of cases. In this work,