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The Evolutionary Role of the IL-33/ST2 System in Host Immune Defence

✍ Scribed by Susanne Sattler, Hermelijn H. Smits, Damo Xu…

Book ID
120911894
Publisher
Springer
Year
2013
Tongue
English
Weight
332 KB
Volume
61
Category
Article
ISSN
0004-069X

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## Background: St2 has been proposed to be a regulator of inflammation and th1/th2 balance. st2l is the il-33 membrane receptor and belongs to the il-1r family. the soluble variant, st2s, is identical to the extracellular region of st2l and competes for il-33 binding, inhibiting receptor signaling.