The evolutionary origin of the vasopressin/V2-type receptor/aquaporin axis and the urine-concentrating mechanism
β Scribed by Juul, Kristian Vinter
- Book ID
- 111879504
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 486 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0969-711X
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Nephrogenic diabetes insipidus (NDI) is associated with germline mutations in two genes: vasopressin receptor type 2 (V2(R)) in X-linked NDI, and the water channel aquaporin-2, in autosomal-recessive disease. Genetic heterogeneity is further emphasized by reports of phenotypically abnormal individua
## Abstract The vasopressin V2 receptor (V2R) belongs to the Class A G proteinβcoupled receptors (GPCRs). V2R is expressed in the renal collecting duct (CD), where it mediates the antidiuretic action of the neurohypophyseal hormone arginine vasopressin (CYFQNCPRGβNH~2~, AVP). Desmopressin ([1βdeami