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The evolution of the Phl-trisomic clone, in a case of chronic myeloid leukemia

โœ Scribed by M. Hussein Khan


Publisher
Springer
Year
1974
Tongue
English
Weight
413 KB
Volume
24
Category
Article
ISSN
0340-6717

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Repetitive DNA hypomethylation in the ad
โœ Jose Roman-Gomez; Antonio Jimenez-Velasco; Xabier Agirre; Juan A. Castillejo; Ge ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 165 KB

Repetitive elements are heavily methylated in normal tissues, but hypomethylated in malignant tissues, driving the global genomic hypomethylation found in cancer. This hypomethylation results in chromosomal instability, a well-characterized feature of the advanced phases of chronic myeloid leukemia