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The Evolution of Catalytic Function in the HIV-1 Protease

✍ Scribed by Manoj Kumar Singh; Kristina Streu; Andrew J. McCrone; Brian N. Dominy


Book ID
116664556
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
742 KB
Volume
408
Category
Article
ISSN
0022-2836

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## Abstract The relative energy between two different protonation sites of the Asp25β€² catalytic site residue is computed and analyzed for various HIV‐1 Protease/inhibitor complexes and compared to the wild‐type structure. By comparing calculations of negatively charged fragments of gradually increa