The Evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death
β Scribed by Kurokawa, M.
- Book ID
- 111746476
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 866 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0261-4189
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Activation of the cβjun Nβterminal kinase (JNK) is known to be an important step during ethanolβinduced cell death, but it has yet to be identified how JNK regulates apoptosis. Therefore, we investigated the mechanism by which JNK induces cell death following ethanol treatment. Ethanol
Human monocytic leukemia U937 cells undergo apoptosis when treated with antitumor drugs, such as etoposide, camptothecin and mitomycin C. The molecular mechanism of the drug-induced apoptosis is not well understood. In this study, we found that 2-deoxyglucose (2DG), an analog of D-glucose and an ind