The evaluation of neuroprotective efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats

✍ Scribed by Jiri Kassa; Jana Karasova; Libor Vasina

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 187 KB
• Volume: 27
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.1273

✦ Synopsis

Abstract

The neuroprotective effects of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI‐6) in combination with atropine in rats poisoned with cyclosarin were studied. The cyclosarin‐induced neurotoxicity was monitored using a functional observational battery at 24 h and 7 days following cyclosarin challenge. The results indicate that the oxime HI‐6 combined with atropine seems to be the most effective antidote for a decrease in cyclosarin‐induced neurotoxicity. Both newly developed oximes (K074, K075) as well as obidoxime are also able to counteract cyclosarin‐induced acute neurotoxicity, but their neuroprotective potency is significantly lower compared with the oxime HI‐6. Therefore, the oxime HI‐6 is still the most suitable oxime for the antidotal treatment of acute poisonings with cyclosarin due to its neuroprotective as well as reactivating efficacy. Copyright © 2007 John Wiley & Sons, Ltd.