The evaluation of a biphasic calcium phosphate ceramic for use in grafting long-bone diaphyseal defects

✍ Scribed by D. C. Moore; Dr. M. W. Chapman; D. Manske

• Publisher: Elsevier Science
• Year: 1987
• Tongue: English
• Weight: 1008 KB
• Volume: 5
• Category: Article
• ISSN: 0736-0266
• DOI: 10.1002/jor.1100050307

✦ Synopsis

The effectiveness of a sintered hydroxyapatite-tricalcium phosphate (HA-TCP) ceramic in bridging large diaphyseal defects in the canine ulna was studied. One-hundred percent morselized HA-TCP, a 50:50 mixture of morselized HA-TCP, and autogenous cancellous bone, and 100% autogenous cancellous bone were used to bridge 2.5-cm defects in the left ulnae of three groups of six dogs each. At 24 weeks the ulnae were explanted and studied by radiography, microradiography, mechanical testing, and histology. Pure HA/TCP was not osteoinductive, and four of six ulnae in this group progressed to a fibrous nonunion. The HA/TCP-cancellous bone mixture and pure cancellous bone were approximately equal in effect, leading to good callus formation at 4 weeks and strong bony union by 24 weeks, with no evidence of bioincompatibility. Morselized HA/TCP promises to be useful as a graft extender when mixed with autogenous cancellous bone.