The ets-1 gene and ataxia telangiectasia
β Scribed by Patrick Concannon
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 719 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0167-5699
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The ataxia-telangiectasia mutated (ATM) gene, which is mutated in the autosomal recessive disorder ataxia-telangiectasia (AT), was isolated in 1995 by positional cloning. Although in vitro cell fusion studies had suggested that AT was genetically heterogeneous, all AT patients studied to date have b
## Abstract We analyzed the role of 4 genes, __TCLβ1__, __MTCPβ1__, __TMLβ1__ and __ATM__, in the early pathogenesis of T cell leukemia, with particular interest in the characteristics of longβstanding nonβleukemic clonal proliferations in ataxiaβtelangiectasia (AβT) patients. Five patients were st