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The ethanol metabolite, linolenic acid ethyl ester, stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stellate cells

โœ Scribed by Jianjun Li; Weimin Hu; Joseph J Baldassare; Puran S Bora; Shuang Chen; John E Poulos; Rosemary O'Neill; Robert S Britton; Bruce R Bacon


Book ID
117985060
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
237 KB
Volume
73
Category
Article
ISSN
0024-3205

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## Abstract Blood vessel injury results in limited oxygen tension and diffusion leading to hypoxia, increased anaerobic metabolism, and elevated production of acidic metabolites that cannot be easily removed due to the reduced blood flow. Therefore, an acidic extracellular pH occurs in the local mi