๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

THE ESTIMATION OF THE PROPORTION OF RECESSIVES FROM TESTS CARRIED OUT ON A SAMPLE NOT WHOLLY UNRELATED

โœ Scribed by FISHER, R. A.

Book ID
115246338
Publisher
Wiley (Blackwell Publishing)
Year
1940
Tongue
English
Weight
524 KB
Volume
10
Category
Article
ISSN
2050-1420

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Saliva and serum samples were collected
Saliva and serum samples were collected from eight healthy volunteers every two hours during a 26-hour period. Melatonin concentrations were measured by radioimmunoassay after chloroform extraction using radioiodinated melatonin as a tracer. Five of the subjects had high serum melatonin levels at night (peak levels higher than 75 pg/ml); in three subjects the highest serum melatonin concentration was 20-40 pg/ml. All subjects had low levels (P <0.001, was obtained for all detectable value pairs (n= 73). The regression and correlation coefficients were almost equal for the peak values of melatonin and during the rising and descending phases of the secretion patterns. However, no significant correlation was found between low daytime salivary and serum concentrations when calculated separately. In the five high-secretors the melatonin levels in saliva reflected reliably the changes in serum, but in the three low-secretors the correlation between salivary and serum melatonin was not significant. The proportion of melatonin found in saliva decreased with increasing serum melatonin levels. Circadian rhythm parameters were estimated by single cosinor analysis. The acrophases did not differ significantly within a subject in the concomitant measurements of serum and salivary melatonin. The measurements of salivary melatonin levels seem valid for studies on melatonin rhythms, but the melatonin concentrations measured in saliva do not always consistently reflect the absolute concentrations in blood.
โœ Maija-Liisa Laakso; Tarja Porkka-Heiskanen; Aino Alila; Dag Stenberg; Gunnar Joh ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 622 KB