## Abstract Pedigrees collected for linkage studies are a valuable resource that could be used to estimate genetic relative risks (RRs) for genetic variants recently discovered in caseβcontrol genome wide association studies. To estimate RRs from highly ascertained pedigrees, a pedigree βretrospect
The estimation of phenotype distributions from pedigree data
β Scribed by Winter, Robin M. ;Optiz, John M.
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 309 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0148-7299
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
It is well known that the maximum likelihood estimates (MLEs) of a multivariate normal distribution from incomplete data with a monotone pattern have closed-form expressions and that the MLEs from incomplete data with a general missing-data pattern can be obtained using the Expectation-Maximization
The distribution and moments of ANOVA estimator of heritability are given under unbalanced random model. These expressions are used to investigate the effect of unbalancedness on the bias and variance/MSE of the estimator and also the validity of certain approximations for its variance, numerically.