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The Estimation of Local Brain Temperature by in Vivo1H Magnetic Resonance Spectroscopy

✍ Scribed by Ernest B. Cady; Patricia C. D'Souza; Juliet Penrice; Ann Lorek

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
572 KB
Volume
33
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Brain temperature may be important for investigating pathology and cerebroprotective effects of pharmaceuticals and hypothermia. Two methods for estimating temperature using ^1^H magnetic resonance spectroscopy are described: a partially water‐suppressed binomial sequence and non‐water‐suppressed point‐resolved spectroscopy. Relative to N‐acetylaspartate (Naa), water chemical shift (θ~H2O‐Naa~) in piglet brain depended linearly on temperature from 30° to 40°C: temperature was 286.9–94.0 θ~H2O‐Naa~ ° C. Thalamic temperature in six normal infants was 38.1° ± 0.4° C indicating that local brain temperature could be estimated with adequate sensitivity for studying pathologic and therapeutic changes.

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