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The estimation of gene frequencies from family records

โœ Scribed by Finney, D J


Book ID
109855601
Publisher
Nature Publishing Group
Year
1948
Tongue
English
Weight
203 KB
Volume
2
Category
Article
ISSN
0018-067X

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## Abstract Family data are useful for estimating disease risk in carriers of specific genotypes of a given gene (penetrance). Penetrance is frequently estimated assuming that relatives' phenotypes are independent, given their genotypes for the gene of interest. This assumption is unrealistic when