The Essence of Linkage-based Imprinting Detection: Comparing Power, Type 1 Error, and the Effects of Confounders in Two Different Analysis Approaches

Examining the effect of linkage disequil

Examining the effect of linkage disequilibrium between markers on the Type I error rate and power of nonparametric multipoint linkage analysis of two-generation and multigenerational pedigrees in the presence of missing genotype data

✍ Yoonhee Kim; Priya Duggal; Elizabeth M. Gillanders; Ho Kim; Joan E. Bailey-Wilso 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 396 KB

## Abstract Because most multipoint linkage analysis programs currently assume linkage equilibrium between markers when inferring parental haplotypes, ignoring linkage disequilibrium (LD) may inflate the Type I error rate. We investigated the effect of LD on the Type I error rate and power of nonpa