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The Escherichia coli adenylate cyclase complex: Regulation by enzyme I of the phosphoenolpyruvate:Sugar phosphotransferase system

✍ Scribed by Alan Peterkofsky; Jose E. Gonzalez; Celia Gazdar


Book ID
115703802
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
823 KB
Volume
188
Category
Article
ISSN
0003-9861

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The Escherichia coli adenylate cyclase c
✍ Peterkofsky, Alan ;Gazdar, Celia πŸ“‚ Article πŸ“… 1978 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 546 KB

A model for the regulation of the activity of Escherichia coli adenylate cyclase is presented. It is proposed that Enzyme I of the phosphoeno1pyruvate:sugar phosphotransferase system (PTS) interacts in a regulatory sense with the catalytic unit of adenylate cyclase. The phosphoenolpyruvate (PEP)-dep

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## Abstract Regulation of lactose uptake by the phosphoenolpyruvate‐sugar phosphotransferase system (PTS) has been demonstrated in membrane vesicles of Escherichia coli strain ML308‐225. Substrates of the phosphotransferase system inhibited D‐lactate energized uptake of lactose but did not inhibit