The Erlenmeyer flask bone deformity in the skeletal dysplasias

✍ Scribed by Maha A. Faden; Deborah Krakow; Fatih Ezgu; David L. Rimoin; Ralph S. Lachman

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 184 KB
• Volume: 149A
• Category: Article
• ISSN: 1552-4825
• DOI: 10.1002/ajmg.a.32253

✦ Synopsis

Abstract

Erlenmeyer flask bone deformity (EFD) is a long‐standing term used to describe a specific abnormality of the distal femora. The deformity consists of lack of modeling of the di‐metaphysis with abnormal cortical thinning and lack of the concave di‐metaphyseal curve resulting in an Erlenmeyer flask‐like appearance. Utilizing a literature review and cohort study of 12 disorders we found 20 distinct disorders were associated with EFD. We interrogated the International Skeletal Dysplasia Registry (ISDR) radiographic database (1988–2007) to determine which skeletal dysplasias or syndromes were highly associated with EFD, whether it was a uniform finding in these disorders, and if forms of EFD could be differentiated. EFD was classified into three groups. The first catogory was the typical EFD shaped bone (EFD‐T) resultant from absent normal di‐metaphyseal modeling with relatively normal appearing radiographic trabecular bone. EFD‐T was identified in: frontometaphyseal dysplasia, craniometaphyseal dysplasia, craniodiaphyseal dysplasia, diaphyseal dysplasia‐Engelmann type, metaphyseal dysplasia‐Pyle type, Melnick–Needles osteodysplasty, and otopalatodigital syndrome type I. The second group was the atypical type (EFD‐A) due to absence of normal di‐metaphyseal modeling with abnormal radiographic appearance of trabecular bone and was seen in dysosteosclerosis and osteopetrosis. The third group was EFD‐marrow expansion type (EFD‐ME) in which bone marrow hyperplasia or infiltration leads to abnormal modeling (e.g., Gaucher disease). Further, radiographic review determined that it was not always a consistent finding and that there was variability in both appearance and location within the skeleton. This analysis and classification aided in differentiating disorders with the finding of EFD. © 2009 Wiley‐Liss, Inc.