Chemoenzymic resolution and deracemisati
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Ian V.J. Archer; David J. Leak; David A. Widdowson
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Article
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1996
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Elsevier Science
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French
โ 170 KB
Corynebacterium C12 epoxide hydrolase transforms (ยฑ)-l-methyl-l,2-epoxycyclohexane 1 to the (I-S, 2-S)-l-methylcyclohexane-l,2-diol 2 leaving the (1-S, 2-R)epoxide 3 unchanged. The diol 2 is converted to the the (l-R, 2-S )-epoxide 4 by sulfonationring closure. A one pot combination of Corynebacteri