The enterohepatic circulation of methotrexate in vivo: Inhibition by bile salt
โ Scribed by Donald Griffin; Hamid M. Said
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 219 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0344-5704
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๐ SIMILAR VOLUMES
We have shown that serum bile acid concentrations are elevated in human infants reflecting physiologic immaturity of the enterohepatic circulation. To define further the ontogeny of bile acid metabolism in mammals, we examined maturational changes in the serum concentration of total cholate conjugat
The lipophilicity of propranolol is increased by some bile salts which form ionpairs. In the presence of taurodeoxycholate, the logarithm of the apparent partition coefficient (log P) of propranolol is increased. Moreover, the apparent diffusion constants in vitro of propranolol as ion-pairs at pH 3