✦ LIBER ✦

The enhancing effect of cell-wall aggressin on the virulence ofStaphylococcus aureusin normal and irradiated mice and in man

✍ Scribed by J. C. M. Vijver; Mary M. Es-Boon; M. F. Michel

Publisher: Springer Netherlands
Year: 1974
Tongue: English
Weight: 389 KB
Volume: 40
Category: Article
ISSN: 0003-6072
DOI: 10.1007/bf00394552

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✦ Synopsis

Mice irradiated with lethal doses of total body X-irradiation are very susceptible to Staphylococcus aureus. A difference in virulence between a "mousevirulent" strain and a "mouse-non-virulent" strain which lacks cell-wall aggressin could nevertheless be demonstrated. The virulence of the "mouse-nonvirulent" strain could be increased by adding a cell-wall preparation with aggressin-activity (DOCR) from a "mouse-virulent" strain to the inoculum. When injected together with a dose of bacteria lower than the minimum pus-forming dose a lesion-enhancing effect of DOCR from a "mouse-virulent" strain was also demonstrated in man.

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