Gene delivery mediated by polyplexes such as DNA complexed with polylysine conjugates is limited by the low ef®ciency of escape of DNA from the endosomes. One of the strategies which favors the transmembrane passage of polyplexes consists of adding anionic amphipathic peptides capable of destabilizi
✦ LIBER ✦
The Enhancing Effect of Anionic α-Helical Peptide on Cationic Peptide-Mediating Transfection Systems
✍ Scribed by Naoya Ohmori; Takuro Niidome; Akihiro Wada; Toshiya Hirayama; Tomomitsu Hatakeyama; Haruhiko Aoyagi
- Book ID
- 115580476
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 109 KB
- Volume
- 235
- Category
- Article
- ISSN
- 0006-291X
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## Abstract In our previous study, we utilized a 26‐residue amphipathic α‐helical antimicrobial peptide L‐V13K (Chen et al., Antimicrob Agents Chemother 2007, 51, 1398–1406) as the framework to study the effects of peptide hydrophobicity on the mechanism of its antimicrobial action. In this study,
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