HeLa cell spreading on a gelatin substrate requires the activation of protein kinase C (PKC), which occurs as a result of cell-attachment-induced activation of phospholipase A2 (PLA2) to produce arachidonic acid (AA) and metabolism of AA by lipoxyginase (LOX). The present study examines how PKC acti
✦ LIBER ✦
The engagement of β1 integrins on promonocytic cells promotes phosphorylation of Syk and formation of a protein complex containing Lyn and β1 integrin
✍ Scribed by Lesley A. Miller; Julie J. Hong; Michael S. Kinch; Marietta L. Harrison; Robert L. Geahlen
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 124 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0014-2980
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Spreading is a critical process involved in motility and growth of tumor cells during the metastatic cascade. Focal adhesion kinase, src-proteins and PKC have been reported to participate in the regulation of cytoskeleton organization in both normal and transformed cells during spreading. The role o