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The energetic ups and downs of protein folding

✍ Scribed by Creighton, Thomas E

Book ID: 109964606
Publisher: Nature Publishing Group
Year: 1994
Tongue: English
Weight: 427 KB
Volume: 1
Category: Article
ISSN: 1072-8368
DOI: 10.1038/nsb0394-135

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The available experimental data on the kinetics of unfolding and refolding of small proteins are reviewed. Excluding slow transitions in the unfolded protein due to cis- trans isomerization of peptide bonds, the rate-limiting transition state in both unfolding and refolding is concluded to be a high