The endothelin/nitric oxide balance determines small-for-size liver injury after reduced-size rat liver transplantation

Minimizing oxidative stress by gene deli

Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat

✍ Thorsten G. Lehmann; Tom Luedde; Robert F. Schwabe; Hartwig Bunzendahl; R. Jude 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 290 KB

Transplantation of reduced-size livers may lead to a hypermetabolic state and increased production of oxygen radicals. Since oxygen radicals may cause liver injury and impair liver regeneration, we tested the hypothesis that overexpression of superoxide dismutase (SOD) in reduced-size livers (RSL) w