The endothelin B (ETB) receptor agonist IRL 1620 is highly vasoconstrictive in two syngeneic rat tumour lines: potential for selective tumour blood flow modification

Modification of blood flow in the HSN tu

Modification of blood flow in the HSN tumour and normal tissues of the rat by the endothelin ETB receptor agonist, IRL 1620

✍ Katrina M. Bell; David J. Chaplin; Beverley A. Poole; Vivien E. Prise; Gillian M 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 208 KB 👁 2 views

Activation of endothelin receptors on the vasculature can produce a variety of responses from potent vasoconstriction to mild vasodilation, depending on the receptor complement within the tissue. To elucidate the potential role of endothelin analogues as tumour blood flow modifiers, we have evaluate