Food restriction can extend life span in rodents and was recently reported to increase the resistance of neurons in the brain to excitotoxic and metabolic insults. In principle, administration to ad libitum fed rodents of an agent that reduces glucose availability to cells should mimick certain aspe
โฆ LIBER โฆ
The Endoplasmic Reticulum Stress-Responsive Protein GRP78 Protects Neurons Against Excitotoxicity and Apoptosis: Suppression of Oxidative Stress and Stabilization of Calcium Homeostasis
โ Scribed by ZaiFang Yu; Hong Luo; Weiming Fu; Mark P. Mattson
- Book ID
- 115606920
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 756 KB
- Volume
- 155
- Category
- Article
- ISSN
- 0014-4886
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The transcription factor NF-B is expressed in neurons wherein it is activated in response to a variety of stress-and injury-related stimuli including exposure to cytokines such as tumor necrosis factor-โฃ (TNFโฃ), and excitotoxic and oxidative insults. NF-B may play a role in the anti-death actions of