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The endoplasmic reticulum and neurological diseases

✍ Scribed by Wei Yang; Wulf Paschen


Book ID
116459583
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
201 KB
Volume
219
Category
Article
ISSN
0014-4886

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The unfolded protein response (UPR) is an evolutionarily conserved cell signaling pathway that is activated to regulate protein synthesis and restore homeostatic equilibrium when the cell is stressed from increased client protein load or the accumulation of unfolded or malfolded proteins. Once activ