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The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)

✍ Scribed by D Smart; M J Gunthorpe; J C Jerman; S Nasir; J Gray; A I Muir; J K Chambers; A D Randall; J B Davis


Book ID
110004757
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
136 KB
Volume
129
Category
Article
ISSN
0007-1188

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The endogenous lipid anandamide is a ful
✍ D Smart; M J Gunthorpe; J C Jerman; S Nasir; J Gray; A I Muir; J K Chambers; A D πŸ“‚ Article πŸ“… 2000 πŸ› Nature Publishing Group 🌐 English βš– 136 KB

The endogenous cannabinoid anandamide was identified as an agonist for the recombinant human VR1 (hVR1) by screening a large array of bioactive substances using a FLIPR‐based calcium assay. Further electrophysiological studies showed that anandamide (10 or 100 μM) and capsaicin (1 μM) produced simil