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The endogenous cofactors, thioctic acid and dihydrolipoic acid, are neuroprotective against NMDA and malonic acid lesions of striatum

✍ Scribed by Greenamyre, J.Timothy; Garcia-Osuna, Monica; Greene, James G.

Book ID: 120051993
Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 380 KB
Volume: 171
Category: Article
ISSN: 0304-3940
DOI: 10.1016/0304-3940(94)90593-2

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## Abstract Symptoms in the early stages of Huntington's disease (HD) are assumed to reflect basal ganglia circuit dysfunction secondary to degeneration of striatal projections to the external segment of the globus pallidus (GPe). The hypothesis that GPe lesion would ameliorate HD symptoms by “norm