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The endocrinologic evaluation of a 45,X true hermaphrodite

✍ Scribed by Rosen, Gregory F.; Vermesh, Michael; d'Ablaing, Gerrit; Wachtel, Stephen; Lobo, Rogerio A.


Book ID
122172366
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
287 KB
Volume
157
Category
Article
ISSN
1097-6868

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A search for Y-specific DNA sequences has been performed in a sample of seven 46,XX true hermaphrodites and one 45,X mixed gonadal dysgenesis case and compared with a sample of 11 XX males. Using six Y-specific DNA probes no hybridization signal was obtained in the hermaphrodite group; in contrast,

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## Yp -specific sequences, including the testicular determinant gene SRY, have been detected and located in a 46,XX true hermaphrodite individual, using PCR amplification and fluorescent in situ hybridization (FISH). Among different Y chromosome loci tested, it was only possible to detect Yp sequen