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The enantioselectivity of modified cyclodextrins: Studies on interaction mechanisms

✍ Scribed by Venema, Arnold ;Henderiks, Harmanna ;v. Geest, Renie

Book ID
102349417
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
447 KB
Volume
14
Category
Article
ISSN
0935-6304

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✦ Synopsis

Abstract

The separation of enantiomers of rather simple molecules, such as alkanes and alkanoic acid esters substituted at the 2‐position, has been investigated on alkylated β‐cyclodextrin stationary phases. By observing the effect of varying the substrate and the cyclodextrin alkylating agent it has been possible to propose a mechanism for the separation. The most important factors seem to be hydrophobic interactions and the ability of the cyclodextrin to change its conformation to accept the guest molecule.

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✍ KΓΆnig, W. A. ;Krebber, R. ;Wenz, G. πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 335 KB

The use of per-0-alkylated as well as partially alkylated/acylated derivatives of a-, p-, and y-cyclodextrins as chiral stationary phases has opened many new applications to enantioselective gas chromatography. Chiral recognition is now independent of hydrogen bonding interactions and enantiomer sep