The hydrophenanthrenone approach to the synthesis of morphinane alkaloids such as (-)-dihydrocodeinone ( 16) is described. Optical activity is achieved by chiral resolution of the hydrophenanthrenone derivative 6 on cellulose triacetate. Key steps of the thirteen-step synthesis are the conjugate add
โฆ LIBER โฆ
The Enantioselective Synthesis of Morphine
โ Scribed by Douglass F. Taber; Timothy D. Neubert; Matthew F. Schlecht
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 8 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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