The Enantioselective Morita–Baylis–Hillman Reaction and Its Aza Counterpart

✍ Scribed by Géraldine Masson; Christopher Housseman; Jieping Zhu

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 398 KB
• Volume: 46
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200604366

✦ Synopsis

Abstract

The development of asymmetric Morita–Baylis–Hillman (MBH) reactions has evolved dramatically over the past few years, parallel to the emerging concept of bifunctional organocatalysis. Whereas organocatalysis is starting to compete with metal‐based catalysis in several important organic transformations, the MBH reaction belongs to a group of prototypical reactions in which organocatalysts already display superiority over their metal‐based counterparts. This Minireview summarizes recent mechanistic insights and advances in the design and synthesis of small organic molecules for enantioselective MBH and aza‐MBH reactions.