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The enantiomer of strychnine is a weak antagonist of the inhibitory glycine receptor

✍ Scribed by Steven D. Knight; Ricardo Miledi; Quoc-Thang Nguyen; Larry E. Overman; Garry Pairaudeau

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 172 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00108-6

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Strychnine, a complex molecule, antagonizes in some unknown manner the action of glycine, an important inhibitory neurotransmitter in the spinal cord and brainstem of many vertebrates. To help understand the mechanism of this antagonism, we have employed modern computational methods to assess the si