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The emerging genetic landscape underlying cardiac conduction system function

✍ Scribed by David E. Arnolds; Alison Chu; Elizabeth M. McNally; Marcelo A. Nobrega; Ivan P. Moskowitz

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
204 KB
Volume
91
Category
Article
ISSN
1542-0752

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✦ Synopsis

Abstract

Proper function of an organized Cardiac Conduction System (CCS) is vital to the survival of metazoans ranging from fly to man. The routine use of non‐invasive electrocardiogram measures in the diagnosis and monitoring of cardiovascular health has established a trove of reliable CCS functional data in both normal and diseased cardiac states. Recent combination of echocardiogram (ECG) data with genome‐wide association studies has identified genomic regions implicated in ECG variability which impact CCS function. In this study, we review the substantial recent progress in this area, highlighting the identification of novel loci, confirming the importance of previously implicated loci in CCS function, and exploring potential links between genes with important roles in developmental processes and variation in function of the CCS. Birth Defects Research (Part A), 2011. © 2011 Wiley‐Liss, Inc.

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