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Effect of molecular structure on the performance of triarylmethane dyes as therapeutic agents for photochemical purging of autologous bone marrow grafts from residual tumor cells

✍ Guilherme L. Indig; Gregory S. Anderson; Michael G. Nichols; Jeremy A. Bartlett; 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 297 KB 👁 2 views

Extensively conjugated cationic molecules with appropriate structural features naturally accumulate into the mitochondria of living cells, a phenomenon typically more prominent in tumor than in normal cells. Because a variety of tumor cells also retain pertinent cationic structures for longer period