The embryology of trypan blue induced abnormalities in mice

✍ Scribed by Hamburgh, Max

• Publisher: John Wiley and Sons
• Year: 1954
• Tongue: English
• Weight: 965 KB
• Volume: 119
• Category: Article
• ISSN: 0003-276X
• DOI: 10.1002/ar.1091190402

✦ Synopsis

Considerable interest centers around the discovery of teratogenic agents and the investigation of their effects on different organisms and their development. The subject of teratogeny may be approached from several viewpoints.

1. Pharmacologists are primarily interested in this field for reason of possible toxicity of drugs.

2. Embryologists, in studies of the role of metabolic gradients in development, have accumulated considerable data on the effects of various metabolic poisons on embryonic tissue, e.g. tithium (Herbst, 1892, for review of later literature see Hall, '47), Mg salts (Stockard, '07). Thus the study of teratogenic effects of different agents has become a tool of experimental embryology.

3. Physiological Geneticists have shown considerable interest in teratogenic agents particularly when the effects of these agents show resemblance to conditions known to arise as the result of gene mutation. The theoretical implications of this type of approach have been stressed by Goldschmidt ( '45) and Landauer ( '48, '52).