The efficiency of aquocobalamine as an antidote in cyanide poisoning when given alone or combined with sodium thiosulfate
✍ Scribed by K. D. Friedberg; U. R. Shukla
- Publisher
- Springer-Verlag
- Year
- 1975
- Tongue
- English
- Weight
- 595 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0340-5761
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✦ Synopsis
The antidotal activities of aquocobalamineacetate and sodium thiosulfate were tested in guinea pigs and cats. The animals were attached to argiilcial respirators throughout the experiment and were poisoned with a continuous infusion of sodium cyanide solution (4.1 V3~Iol/kg 9 min I~aCN).
The rate of action of each antidote was determined from the time taken for the HCN exhalation to drop below the level of t00 ni~ol/kg 9 rain in guinea pigs, and to values below 25 n_Mol/kg 9 rain in cats; the detoxifying capacity of each antidote was determined from the time taken for the HC~ exhalation to rise above the said values and the time interval for normal function of heart activity to be restored.
Aquocobalamine was characterized by its rapid rate of reaction in both the animal species; its detoxifying capacity showed, however, according to our expectations, variations corresponding to the applied doses.
The combination of the antidotes aquoeobalamine (100 mg/kg) and thiosulfate (500 mg/kg) proved to possess high rate of reaction and a large detoxifying Cal~acity in guinea pigs. Similar results were obtained in cata with antidote doses of 200 mg/kg aquocobalamine combined with 500 mg/kg thiosulfate.
The slow rate of reaction and large detoxifying capacity of thiosulfate were confirmed in our experiments. Its combination with aquocobalamine showed no undesirable change in its antidotal action providing a time interval of i rain was maintained between the 2 injections.