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The efficacy of psoralen photochemotherapy in the treatment of aquagenic pruritus

✍ Scribed by H. DU P. MENAGÉ; P.G. NORRIS; J.L.M. HAWK; M.W. GREAVES

Book ID
108664458
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
232 KB
Volume
129
Category
Article
ISSN
0007-0963

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Photochemotherapy employing 8-methoxypsoralen and ultraviolet radiation (PUVA) is widely used in the treatment of psoriasis. The photoactivation of psoralens in skin cells leads to DNA photoadduct formation which may be responsible for the efficacy of PUVA. Subsequent mutations may lead to the incre