The efficacy of an antioxidant cocktail on lipid peroxide level and superoxide dismutase activity in aged rat brain and DNA damage in iron-induced epileptogenic foci
✍ Scribed by M Komatsu; M Hiramatsu
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 111 KB
- Volume
- 148
- Category
- Article
- ISSN
- 0300-483X
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✦ Synopsis
Mixed natural antioxidants can be combined in a prophylactic food against age related disease involving reactive oxygen species. b-Catechin is an antioxidant drink, having free radical scavenging activities. It contains green tea extract as a main component as well as ascorbic acid, sunflower seed extract, dunaliella carotene and natural vitamin E. In the present study, we examined the effect of b-catechin on lipid peroxide formation and superoxide dismutase (SOD) activity in aged rat brain and the effect on 8-hydroxy-2%-deoxyguanosine (8-OHdG) in ipsilateral cortex, 30 min after ferric chloride solution was injected into the left cortex of rats. b-Catechin solution was orally administered to aged rats and normal rats for 1 month. One-month administration of b-catechin solution increased SOD activity in the mitochondria fraction of striatum and midbrain and decreased thiobarbiturate reactive substance formation in the cortex and cerebellum of aged rats. It also inhibited 8-OHdG formation in the ipsilateral cortex 30 min after injection of ferric chloride solution. These results suggest that b-catechin is a suitable prophylactic beverage against age-related neurological diseases associated with reactive oxygen species.