The effects on human skin after repetitive ultraviolet-A1 (UVA1) irradiation
โ Scribed by EDSTROM, D
- Book ID
- 122798905
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 127 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0926-9959
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The effects of UVA, mixed UVA + B, and solar-simulated irradiation were examined in human keratinocytes and melanocytes cultured in vitro. Irradiation with UVA, UVA + B, or the solar simulator caused a dose-dependent decrease in keratinocyte cell numbers and thymidine incorporation at 24 hours, with
Ultraviolet B (UVB) irradiation of the skin causes immunosuppression which is relevant to the induction of skin cancer. The mechanism of this immunomodulation is unclear but various regulatory molecules have been implicated, including cis-urocanic acid (cis-UCA) and the cytokines tumour necrosis fac