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The effects of Tween 20 and sucrose on the stability of anti-L-selectin during lyophilization and reconstitution

โœ Scribed by Latoya S. Jones; Theodore W. Randolph; Ulrich Kohnert; Apollon Papadimitriou; G. Winter; Marie-Luise Hagmann; Mark C. Manning; John F. Carpenter

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
232 KB
Volume
90
Category
Article
ISSN
0022-3549

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## Purpose: To investigate the effect of plasticizers on the stability of protein formulations in the solid state and to apply these results to a study of mechanisms of protein stabilization by sugars in the solid sate. ## Methods: The igg1 antibody was formulated with either sucrose or trehalose