In this work we report the disruption of a Saccharomyces cerevisiae ORF YBR008c (FLR1 gene) within the context of EUROFAN (EUROpean Functional Analysis Network) six-pack programme, using a PCR-mediated gene replacement protocol as well as the results of the basic phenotypic analysis of a deletant st
The effects of transcription regulating genes PDR1, pdr1–3 and PDR3 in pleiotropic drug resistance
✍ Scribed by Arkadiusz Nawrocki; Stephen J. Fey; André Goffeau; Peter Roepstorff; Peter Mose Larsen
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 204 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1615-9853
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract __NKX3.1__ is a homeobox gene, expression of which is largely restricted to the adult prostatic epithelium. Loss of NKX3.1 expression has been linked to prostate carcinogenesis and disease progression and occurs in the absence of mutations in the coding region of the __NKX3.1__ gene. In
Cyclin-dependent kinase inhibitors play a significant role in cell cycle progression and in cellular differentiation and their expression is regulated in different cellular settings. GC-rich regions in the promoter sequences of the cyclin-dependent kinase inhibitor genes p15INK4B and p21CIP1/WAF1 me
P-glycoproteins encoded by the (multi-drug resistance) mdr genes play a central role in the resistance of tumor cells to a wide range of anti-cancer drugs. Modulation of P-glycoprotein function could therefore provide a means of sensitising tumor cells to chemotherapy. Studies in this context have c
## Abstract Receptor activator of nuclear factor kappa B ligand (RANKL), a potent regulator of osteoclast formation and function, is expressed by osteoblasts and bone marrow stromal cells. However, the molecular mechanism underlying RANKL expression in osteoblast/stromal cells remains largely uncle