The effects of thiamin on the tissue distribution of lead

✍ Scribed by Jin Suk Kim; Barry R. Blakley; Colin G. Rousseaux

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 377 KB
• Volume: 10
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550100206

✦ Synopsis

Abstract

The effects of thiamin on the tissue distribution of lead were evaluated in Sprague–Dawley rats exposed to 1000 ppm lead acetate in drinking water and treated daily with thiamin (25 or 50 mg kg^−1^ body weight, i.p.), calcium ethylenediamine tetraacetic acid (50 mg kg^−1^ body weight, i.p.) or their combination for 8 weeks. The subtoxic dose of lead did not alter weight gains, feed and water consumption during the treatment period. Thiamin decreased the blood (P > 0.0001), liver (P < 0.0001) and kidney (P < 0.0001) concentrations of lead. Thiamin (50 mg kg^−1^ body weight) reduced the lead concentrations in tissues more effectively than thiamin (25 mg kg^−1^ body weight). The combined treatment was more effective than the respective individual treatments.