The effects of testosterone propionate and testosterone cyclopentylpropionate upon morbidity and mortality in mice following lethal total-body irradiation
✍ Scribed by Mitchell W. Spellman; James C. Carlson; C. Walton Lillehei
- Publisher
- John Wiley and Sons
- Year
- 1954
- Tongue
- English
- Weight
- 409 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
AGENTS able to diminish the M morbidity and mortality of exposure to ionizing radiation have immense practical as well as theoretical significance. It has been suggested that methods for augmenting the resistance of the host cells to radiation injury might be utilized in the roentgen-ray therapy of malignant tumors, especially if the tolerance of the neoplastic cells to radiation was not comparably enhanced. Moreover, the possibility of radiation injury suddenly involving large segments of the population creates another obvious and urgent need for such agents or methods.
This present study upon the effects of certain of the androgenic anabolic hormones on radiation morbidity and mortality in mice is a portion of an over-all investigation of the influence of the anabolic hormones upon exposure to lethal doses of total-body irradiation.
Methods
Inbred male mice, 6 weeks of age, of the ABC strain (Bittner) were used for the study. At this age, the average weight of the mice was 20.0 gm. The diet consisted entirely of fox chow pellets and water, both of which were provided ad libitum. T h e animals were observed in the colony for at least one week prior to radiation exposure in order to permit accliniatization. During this interval those mice that appeared physically unsatisfactory were withdrawn from the study before irradiation. Also, if a death occurred in the colony during