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The effects of surgical and chemical lesions on striatal [3H]threo-(±)-methylphenidate binding: Correlation with [3H]dopamine uptake

✍ Scribed by Aaron Janowsky; Margaret M. Schweri; Paul Berger; Robert Long; Phil Skolnick; Steven M. Paul


Book ID
115879628
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
332 KB
Volume
108
Category
Article
ISSN
0014-2999

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Mercuric chloride was found to have a biphasic effect on the binding of the radiolabeled stimulant [3H]methylphenidate to membranes from a crude synaptoso-ma1 preparation of rat striatal tissue. Binding was enhanced at low concentrations of HgCl,, reaching a maximum of 62% above control values at 2.